Key result
5-fluorouracil chemotherapy was associated with a 19% incidence of reversible angina pectoris, alongside significant increases in bradycardia and ventricular extrasystoles (p < 0.05).
Why the study?
What is the incidence of angina pectoris and arrhythmias in patients treated with 5-fluorouracil chemotherapy?
Population
102 consecutive and unselected patients scheduled for 5-fluorouracil (5-FU) chemotherapy
Design
Cohort
Follow-up
3 months
Authors
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May support cardiac monitoring during 5-FU; hypothesis-generating and requires prospective confirmation.
Cohort (n=102)
What is the incidence of angina pectoris and arrhythmias in patients treated with 5-fluorouracil chemotherapy?
5-fluorouracil chemotherapy is associated with a high incidence (19%) of angina pectoris and increased arrhythmias, highlighting the need for cardiac monitoring during treatment.
Wacker et al. (2003) conducted a cohort in Patients undergoing 5-fluorouracil chemotherapy (n=102). 5-fluorouracil (5-FU) chemotherapy vs. Baseline and 3 months post-treatment was evaluated on Reversible symptoms of angina pectoris during treatment. 5-fluorouracil chemotherapy was associated with a 19% incidence of reversible angina pectoris, alongside significant increases in bradycardia and ventricular extrasystoles (p < 0.05).
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