Key result
Intravenous infusion of 5-fluorouracil induced typical angina and ECG changes in a 43-year-old man despite normal coronary angiography.
Case Report (n=1)
5-fluorouracil infusion can induce typical angina and ischemic ECG changes even in patients without significant coronary artery disease.
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5-FU may provoke angina and ECG changes despite normal coronaries; hypothesis-generating and should not yet change practice.
This article reviews the occurrence of angina in patients treated with 5-fluorouracil (5-FU) without significant coronary artery disease. We present a case followed by a review of the literature. A 43-year-old man with a history of colon cancer developed typical angina during intravenous infusion of 5-FU. His electrocardiogram (ECG) showed tall T waves during his angina episode. His angina and ECG changes reoccurred during a second 5-FU infusion. His coronary angiography was normal. This case is consistent with a rare occurrence of 5-FU-induced angina despite normal coronaries. Physician should be aware of this important side effect of 5-FU infusion.
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Tajik et al. (2010) conducted a case report in Colon cancer (n=1). 5-fluorouracil (5-FU) was evaluated on Angina and ECG changes. Intravenous infusion of 5-fluorouracil induced typical angina and ECG changes in a 43-year-old man despite normal coronary angiography.
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