Population
Chow-fed C57BL/6J mice with a GLUT4 partial knockout (GLUT4), hexokinase II overexpression (HK), or both (HK…
Comparison
Insulin clamp and a 2-deoxy[H]glucose bolus. vs 120-min saline infusion.
Design
Preclinical
Follow-up
120 minutes
Authors
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Hexokinase overexpression unmasks GLUT4 limitation in mouse muscle glucose uptake; leaves open relevance to human insulin resistance.
A 50% reduction of normal GLUT4 content does not impair insulin-stimulated muscle glucose uptake unless the glucose phosphorylation barrier is lowered by hexokinase overexpression.
Fueger et al. (2004) studied this question.
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