Why the study?
Does AMPK stimulation by AICAR increase glucose and LCFA clearance in cardiac muscle in vivo?
Does AMPK stimulation by AICAR increase glucose and LCFA clearance in cardiac muscle in vivo?
In vivo AMPK stimulation increases long-chain fatty acid clearance but not glucose clearance in cardiac muscle via a NOS-independent mechanism.
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Rodent data should not guide cardiac substrate use in patients; leaves open AMPK's differential effects on human myocardial LCFA clearance.
Shearer et al. (2004) studied this question.
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