Population
Perfused rat heart model, permeabilized fibers, and rat heart mitochondria subjected to ischemia-reperfusion…
Comparison
Diazoxide pretreatment vs 5-hydroxydecanoate and/or untreated…
Design
Preclinical
Authors
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Animal findings on mitoK(ATP)-dependent membrane preservation are hypothesis-generating; human translation and clinical testing remain needed.
Opening the mitochondrial ATP-sensitive K+ channel with diazoxide protects the ischemic heart by maintaining intermembrane space structure, preserving adenine nucleotides, and reducing ATP hydrolysis during ischemia.
Santos et al. (2002) studied this question.
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