An Endogenous Digoxin-like Substance and Renal Failure

Letters and Corrections1 April 1984An Endogenous Digoxin-like Substance and Renal FailureV.J. HEAZLEWOOD, M.B., B.S., R.L. HEAZLEWOOD, M.SC., L.B. JELLETT, B.S., M.D.V.J. HEAZLEWOOD, M.B., B.S., R.L. HEAZLEWOOD, M.SC., L.B. JELLETT, B.S., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-618_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Graves and colleagues (1) raises serious implications concerning the measurement and subsequent interpretation of plasma digoxin levels in adult patients with renal failure, using radioimmunoassay and enzyme immunoassay techniques. Inherent interference problems with immunoassays may be related to the presence of as yet unspecified plasma proteins (2).With the retention of middle molecules and elevated glycoprotein levels in renal failure, it would appear desirable to assay digoxin in such patients using a method involving protein precipitation. A new fluorescence polarization immunoassay (TDx System; Abbott Laboratories, Diagnostics Division, North Chicago, Illinois), using prior 5% trichloroacetic...References1. GRAVES S, BROWN B, and VALDES R. An endogenous digoxin-like substance in patients with renal impairment. Ann Intern Med. 1983;99:6048. LinkGoogle Scholar2. KERGUERIS M, BOURIN M, LE NORMAND Y, BRIAND C, FRISON B, and LAROUSSE C. Interference of serum proteins during the assay of blood digoxin by various immunologic methods (EMIT, ELISA, RIA). Therapie. 1983;38:117-8. MedlineGoogle Scholar3. PUDEK M, SECCOMBE D, WHITFIELD M, and LING E. Digoxin-like immunoreactivity in premature and full-term infants not receiving digoxin therapy. N Engl J Med. 1983;308:904-5. CrossrefMedlineGoogle Scholar4. SCHREIBER V, GREGOROVÁ I, PRIBYL T, and STEPÁN J. Digitalis-like biological activity and immunoreactivity in chromatographic fractions of rabbit adrenal extract. Endocrinol Exp (Bratisl). 1981;15:229-36. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: V.J. HEAZLEWOOD, M.B., B.S.; R.L. HEAZLEWOOD, M.SC.; L.B. JELLETT, B.S., M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPredictive Performance Study of Two Digoxin Assays in Subjects With Various Degrees of Renal FunctionPhysiological and Pharmacological Properties of an Endogenous Sodium Pump InhibitorThe Effect of Everyday Exercise on Steady State Digoxin ConcentrationsA Comparative Trial of Digoxin and Digitoxin in the Treatment of Congestive Heart FailureDelayed digoxin toxicity following discontinuance in acute renal failureHigh-performance liquid chromatographic analysis of an endogenous digoxin-like immunoreactive substance in uremic serumEndogenous Digitalis-Like FactorsEndogenous Digoxin-like Substance(s) and Combined Hepatic and Renal FailureM. HENRY GAULT, M.D., SUDESH C. VASDEV, PH.D., LINDA L. LONGERICH, M.SC. 1 April 1984Volume 100, Issue 4Page: 618-618KeywordsBlood plasmaDiagnostic techniquesEnzyme immunoassayGlycoproteinsImmunoassaysPlasma proteinsProteinsRadioimmunoassaysRenal failure ePublished: 1 December 2008 Issue Published: 1 April 1984 PDF downloadLoading ...