Why the study?
Does renal impairment cause false-positive or discrepant digoxin measurements on immunoassays due to an endogenous substance?
Population
156 patients with renal impairment and an unspecified number of patients with normal renal function…
Comparison
Measurement of serum digoxin concentrations… vs Patients with normal renal function receiving…
Design
Cross-sectional
Authors
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Clinicians should question digoxin immunoassay results in renal impairment; cross-sectional data leaves open endogenous interference and assay standardization.
Does renal impairment cause false-positive or discrepant digoxin measurements on immunoassays due to an endogenous substance?
Patients with renal impairment possess an endogenous digoxin-like substance that can cause false-positive results and significant discrepancies across different digoxin immunoassays, compromising clinical interpretation.
Steven W. Graves (1983) studied this question.
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