Key result
Patients with congestive heart failure receiving digoxin had a significantly lower ratio of free to total digoxin compared to patients receiving digoxin for other reasons (52.8% vs 72.7%, P<0.05).
Why the study?
Does monitoring free digoxin instead of total digoxin eliminate interference from digoxin-like immunoreactive substances (DLIS) in patients with congestive heart failure?
Population
68 individuals, comprising 12 patients with congestive heart failure not receiving digoxin, 22 normal…
Comparison
Measurement of free digoxin concentrations and… vs Measurement of total digoxin; comparison with…
Design
Cross-sectional
Authors
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Free digoxin monitoring may reduce DLIS interference in CHF; hypothesis-generating for assay choice pending prospective validation.
Observational (n=68)
Does monitoring free digoxin instead of total digoxin eliminate interference from digoxin-like immunoreactive substances (DLIS) in patients with congestive heart failure?
Absolute Event Rate: 52.8% vs 72.7%
p-value: p=<0.05
Monitoring free digoxin rather than total digoxin in CHF patients helps eliminate interference from digoxin-like immunoreactive substances, which can falsely elevate total digoxin measurements.
Dasgupta et al. (1990) conducted an observational in Congestive heart failure (n=68). Congestive heart failure vs. Patients without congestive heart failure was evaluated on Ratio of free to total digoxin (p=<0.05). Patients with congestive heart failure receiving digoxin had a significantly lower ratio of free to total digoxin compared to patients receiving digoxin for other reasons (52.8% vs 72.7%, P<0.05).
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