June 1, 2006Therapeutic Drug Monitoring

Suspected DLIS Interference in the Dimension DGNA Digoxin Assay Method and the Clinical Application of the Revised Digoxin Target Range

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Population

1 elderly female patient with heart failure and renal dysfunction treated with digoxin

Design

Case_report

Authors

RMRaymond G. MorrisSt George's Hospital TJTerry E. JonesUniversity of Liverpool SGSharon GoldsworthySouth Australia Pathology

Discussion

Member takes

Implication

Potential assay interference warrants caution in digoxin TDM interpretation; case reports leave open the prevalence and mitigation of such discrepancies.

Structured PICO

Population

1 elderly female patient with heart failure and renal dysfunction treated with digoxin

Intervention

Measurement of plasma digoxin levels using different immunoassay methods (DRI, DGNA, mFPIA) and ultrafiltration

Outcome

Discrepancy in measured plasma digoxin levels between assayssurrogate

Highlights the importance of careful method selection in therapeutic drug monitoring to avoid inappropriate digoxin dosage adjustments due to assay interference.

Limitations

Further study required to verify that the DLIS implicated was indeed the interfering species

Cite This Study

Morris et al. (2006) studied this question.

synapsesocial.com/papers/6a73f2cfcd7b40c8110ddb6f https://doi.org/10.1097/01.ftd.0000211818.35182.cb

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Implication

Potential assay interference warrants caution in digoxin TDM interpretation; case reports leave open the prevalence and mitigation of such discrepancies.

Suspected DLIS Interference in the Dimension DGNA Digoxin Assay Method and the Clinical Application of the Revised Digoxin Target Range

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Suspected DLIS Interference in the Dimension DGNA Digoxin Assay Method and the Clinical Application of the Revised Digoxin Target Range

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider