Key result
An enzyme immunoassay yielded a falsely elevated serum digoxin concentration of 5.0 ng/ml due to marked digoxin-like immunoreactive factor interference, whereas fluorescence polarization immunoassay results were within the therapeutic range.
Case Report (n=1)
Digoxin-like immunoreactive factors in patients with renal insufficiency can cause marked false elevations in serum digoxin levels measured by enzyme immunoassay, necessitating verification with alternative methods.
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May prompt assay verification for unexpected digoxin levels in renal insufficiency; case report leaves open the prevalence of DLIF interference.
Karboski et al. (1988) conducted a case report in Renal insufficiency (n=1). Enzyme immunoassay vs. Fluorescence polarization immunoassay was evaluated on Serum digoxin concentration (SDC). An enzyme immunoassay yielded a falsely elevated serum digoxin concentration of 5.0 ng/ml due to marked digoxin-like immunoreactive factor interference, whereas fluorescence polarization immunoassay results were within the therapeutic range.
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