Key result
Elderly age was associated with a higher frequency of digoxin-like immunoreactive substance than young controls (P=0.01), which became insignificant after excluding intravenous sodium infusions.
Why the study?
Do clinical factors such as continuous intravenous drip infusion therapy or elderly age increase the presence of digoxin-like immunoreactive substance (DLIS) in patients not taking cardiac glycosides?
Population
341 subjects not administered cardiac glycosides, spironolactone, or canrenone, comprising 220 elderly…
Comparison
Evaluation of clinical factors, specifically… vs Control subjects younger than 35 years of age.
Design
Cross-sectional
Authors
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Continuous intravenous infusion of sodium-containing solutions, rather than age itself, appears to be the primary driver of false-positive digoxin assays (DLIS) in elderly patients.
Observational (n=341)
Do clinical factors such as continuous intravenous drip infusion therapy or elderly age increase the presence of digoxin-like immunoreactive substance (DLIS) in patients not taking cardiac glycosides?
p-value: p=0.01
Continuous intravenous infusion of sodium-containing solutions, rather than age itself, appears to be the primary driver of false-positive digoxin assays (DLIS) in elderly patients.
Yamamoto et al. (1998) conducted an observational in Patients not administered cardiac glycosides (n=341). Elderly age (≥65 years) vs. Young age (<35 years) was evaluated on Frequency of digoxin-like immunoreactive substance (DLIS) (p=0.01). Elderly age was associated with a higher frequency of digoxin-like immunoreactive substance than young controls (P=0.01), which became insignificant after excluding intravenous sodium infusions.
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