Key result
Biotransformation of digoxin was comparable between dialysis-dependent renal failure patients and control subjects (76% vs. 73%), though endogenous digitalis-like factors were significantly increased.
Why the study?
How do biotransformation and endogenous digitalis-like factors affect the interpretation of serum digoxin concentrations in patients with renal failure?
Observational
How do biotransformation and endogenous digitalis-like factors affect the interpretation of serum digoxin concentrations in patients with renal failure?
Absolute Event Rate: 76% vs 73%
In patients with renal failure, biotransformation of digoxin is comparable to controls, and while endogenous digitalis-like factors are elevated, they rarely reach clinical significance on standard immunoassays.
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Supports similar digoxin assay interpretation in renal failure; leaves open clinical impact of elevated endogenous factors.
Gault et al. (1986) conducted an observational in Renal failure. Renal failure (dialysis dependence) vs. Control subjects was evaluated on Biotransformation (percent true digoxin in serum). Biotransformation of digoxin was comparable between dialysis-dependent renal failure patients and control subjects (76% vs. 73%), though endogenous digitalis-like factors were significantly increased.
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