Why the study?
Because renal failure decreases digoxin clearance and is common in heart failure, patients with renal failure are at higher risk of digoxin toxicity given its narrow therapeutic level.
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May warrant reduced digoxin loading doses in CKD; leaves open optimal protocols for toxicity prevention.
Background: Digoxin is a medication of Glycoside family which is commonly prescribed for patients with atrial fi brillation, atrial fl utter, and heart failure. With a narrow therapeuticlevel(0.5-2 ng/mL), careful monitoring of digoxin blood level is necessary. Symptoms of digoxin toxicity include nausea, vomiting, visual changes, altered mental status, hyperkalemia, and cardiovascular collapse. As renal failure decreases the clearance of digoxin, and impaired renal function is common in heart failure, this population is at higher risk of toxicity.
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Eslami et al. (2021) studied this question.
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