Key result
Pharmacokinetic-guided reduction of digoxin maintenance dose to 62.5 micrograms on alternate days resolved toxicity symptoms in a patient with heart failure and worsening renal function.
Population
1 patient, 59-year-old Caucasian male with advanced congestive heart failure, atrial fibrillation…
Design
Case_report
Authors
Loading...
Supports pharmacokinetic-guided digoxin dosing in heart failure with renal impairment; leaves open prospective validation before broader adoption.
Case Report (n=1)
Pharmacokinetic principles should be applied to optimize digoxin dosing in patients with heart failure, atrial fibrillation, and worsening renal function to prevent toxicity.
Arun K Bhindi (2010) conducted a case report in Digoxin toxicity (n=1). Digoxin dose optimization was evaluated on Clinical improvement and resolution of toxicity. Pharmacokinetic-guided reduction of digoxin maintenance dose to 62.5 micrograms on alternate days resolved toxicity symptoms in a patient with heart failure and worsening renal function.