Key result
Accumulation and immunoassay cross-reactivity of cardioinactive metabolites of digoxin caused false elevations in serum digoxin concentration (peak 8.6 ng/ml) in a patient with renal and hepatic dysfunction.
Population
A 41-year-old man with combined renal and hepatic dysfunction
Design
Case_report
Authors
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Clinicians should interpret digoxin levels cautiously in combined renal-hepatic dysfunction; leaves open need for validated metabolite-specific assays.
Case Report (n=1)
Combined renal and hepatic dysfunction can lead to false-positive digoxin measurements due to the accumulation of cardioinactive metabolites.
Vlasses et al. (2008) conducted a case report in Combined renal and hepatic dysfunction (n=1). Digoxin measurement was evaluated on False elevation in digoxin concentration. Accumulation and immunoassay cross-reactivity of cardioinactive metabolites of digoxin caused false elevations in serum digoxin concentration (peak 8.6 ng/ml) in a patient with renal and hepatic dysfunction.
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