Why the study?
What are the pharmacokinetic profiles and time to therapeutic serum concentrations of different digoxin dosing regimens in elderly patients?
Population
29 elderly patients, including 23 with normal renal function undergoing digitalisation for cardiac failure…
Design
Cohort
Authors
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May support loading doses for faster therapeutic digoxin levels in elderly renal impairment; hypothesis-generating and requires randomized confirmation before practice change.
What are the pharmacokinetic profiles and time to therapeutic serum concentrations of different digoxin dosing regimens in elderly patients?
In elderly patients, a loading dose of 0.75 mg digoxin achieves therapeutic serum concentrations by the first day without toxicity, while renal impairment significantly prolongs digoxin half-life.
Caird et al. (1977) studied this question.
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