Why the study?
How does the state of cardiac compensation affect the renal excretion of digitoxin in cardiac patients?
Population
Cardiac patients who were either decompensated or compensated.
Design
Cohort
Authors
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May warrant toxicity caution with standard doses in acute decompensation; leaves open confirmation of dose adjustment needs in biventricular failure.
How does the state of cardiac compensation affect the renal excretion of digitoxin in cardiac patients?
Renal excretion of digitoxin is impaired during acute biventricular decompensation, and daily doses exceeding 0.15 mg risk toxicity due to limited metabolic clearance.
Friedman et al. (1952) studied this question.
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