Key result
Administration of C14-digitoxin in 3 subjects with cardiac insufficiency demonstrated that 60 to 80% of the dose is eliminated via the kidneys, with metabolites detectable up to 74 days.
Observational (n=3)
The major route of elimination of digitoxin in cardiac patients is through the urinary route, with excretion continuing for over two months.
Authors
No takes yet. Share an insight, caveat, or question.
Prolonged renal excretion of digitoxin in HF warrants dosing caution in renal impairment; leaves open validation in larger modern cohorts.
Okita et al. (1953) conducted an observational in Cardiac insufficiency (n=3). C14-digitoxin was evaluated on Renal excretion of unchanged digitoxin and its metabolites. Administration of C14-digitoxin in 3 subjects with cardiac insufficiency demonstrated that 60 to 80% of the dose is eliminated via the kidneys, with metabolites detectable up to 74 days.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: