Key result
Radioactive digitoxin and its derivatives showed prolonged cardiac and renal retention, supporting the concept of storage for cumulative action, with a suggestive increase in metabolism in heart failure.
Preclinical evidence suggests that the cumulative action of cardiac glycosides is due to prolonged cardiac and renal retention, with potentially increased metabolism in heart failure.
No takes yet. Share an insight, caveat, or question.
Supports digitoxin storage for cumulative action in animal models; leaves open human validation of HF metabolism effects.
Fischer et al. (1952) studied Dietary induced myocardial lesions. Radioactive digitoxin was evaluated on Tissue distribution and excretion of radioactive digitoxin and its metabolites. Radioactive digitoxin and its derivatives showed prolonged cardiac and renal retention, supporting the concept of storage for cumulative action, with a suggestive increase in metabolism in heart failure.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: