Key result
Alagebrium acutely attenuated methylglyoxal-induced glucose intolerance and reduced MG levels in plasma and tissues in Sprague-Dawley rats.
Why the study?
Does alagebrium attenuate acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats?
Population
Sprague-Dawley rats treated with methylglyoxal (MG) at doses of either 17.25 mg/kg i.p. or 50 mg/kg i.v.
Comparison
Alagebrium 100 mg/kg i.p. vs Methylglyoxal (MG) treatment without alagebrium
Design
Preclinical
Follow-up
acute
Authors
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May support further preclinical metabolic studies; leaves open translation to human glucose intolerance.
Does alagebrium attenuate acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats?
Alagebrium acutely attenuates methylglyoxal-induced glucose intolerance and reduces MG levels in a rat model, suggesting a potential preventive role against MG's harmful metabolic effects.
Dhar et al. (2009) studied Methylglyoxal-induced glucose intolerance. Alagebrium vs. Methylglyoxal alone was evaluated on Plasma MG levels, glucose tolerance, adipose tissue glucose uptake, GLUT4, insulin receptor and IRS-1 protein expression. Alagebrium acutely attenuated methylglyoxal-induced glucose intolerance and reduced MG levels in plasma and tissues in Sprague-Dawley rats.
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