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October 29, 2011Nephrology Dialysis TransplantationOpen Access

High-salt diet increases glomerular ACE/ACE2 ratio leading to oxidative stress and kidney damage

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Key result

A high-salt diet significantly increased the glomerular ACE/ACE2 ratio and promoted oxidative stress, which could be prevented by ACE inhibition.

Population

48 rats post-left uninephrectomy and 20-week-old Ace2-knockout (Ace2KO) mice

Comparison

High-salt diet and ACE inhibition vs Different dietary salt contents and no ACE…

Design

Preclinical, randomly allocated

Follow-up

4 weeks (for rats)

Authors

SBStella BernardiOspedale di CattinaraBTBarbara ToffoliOspedale di CattinaraCZCristina ZennaroUniversity of Trieste

Discussion

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Implication

High-salt diet may promote glomerular oxidative stress via ACE/ACE2 imbalance in animals; human renal protection by ACE inhibition remains untested.

Structured PICO

P
Population
48 rats undergoing left uninephrectomy and 20-week-old Ace2-knockout mice studied to assess the effects of high-salt diet and ACE inhibition on renal oxidative stress.
I
Intervention
High-salt diet (in rats) and ACE inhibition (in Ace2KO mice)
C
Comparator
Different dietary salt contents (in rats) and no ACE inhibition (in Ace2KO mice)
O
Outcome
Kidney functional, structural, and molecular changes (specifically glomerular ACE/ACE2 ratio and oxidative stress)surrogate

A high-salt diet may induce renal damage by increasing the ACE/ACE2 ratio, leading to AngII-mediated oxidative stress.

Cite This Study

Bernardi et al. (2011) studied Salt-driven kidney damage (n=48). High-salt diet vs. Different dietary contents of salt was evaluated on Glomerular ACE/ACE2 ratio and oxidative stress. A high-salt diet significantly increased the glomerular ACE/ACE2 ratio and promoted oxidative stress, which could be prevented by ACE inhibition.

synapsesocial.com/papers/6a8c42530ca85c7e33df3473https://doi.org/10.1093/ndt/gfr600
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