Key result
Peripheral blood leukocyte telomere length was not associated with left ventricular mass or systolic function, but was positively associated with left ventricular filling parameters including the E/A ratio (b=0.0264, P<0.001).
Cross-Sectional (n=2,509)
No
Effect estimate: b = 0.0264
p-value: p=<0.001
In a generally healthy, young to middle-aged population, shorter leukocyte telomere length is associated with an altered left ventricular filling pattern, especially in women, but not with left ventricular mass or systolic function.
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Telomere length should not guide LV assessment now; leaves open links to preclinical diastolic changes in longitudinal data.
Denil et al. (2014) conducted a cross-sectional in Healthy volunteers (n=2,509). Peripheral blood leukocyte telomere length was evaluated on Transmitral flow early (E) to late (A) velocity ratio (E/A-ratio) (b = 0.0264, p=<0.001). Peripheral blood leukocyte telomere length was not associated with left ventricular mass or systolic function, but was positively associated with left ventricular filling parameters including the E/A ratio (b=0.0264, P<0.001).
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