Why the study?
The study aimed to explore the relationship between the SIRT3 gene and endothelial cell dysfunction contributing to hyperglycemia-driven progression of coronary atherosclerosis.
Is SIRT3 expression associated with coronary artery disease in T2DM patients and does it regulate endothelial cell function under hyperglycemic conditions?
Is SIRT3 expression associated with coronary artery disease in T2DM patients and does it regulate endothelial cell function under hyperglycemic conditions?
SIRT3 is associated with coronary atherosclerosis in T2DM patients and may protect against endothelial dysfunction under hyperglycemic conditions by regulating PPAR-α, eNOS, and iNOS.
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SIRT3 may mark CAD in T2DM; leaves open whether targeting it protects endothelium in humans.
Gong et al. (2022) studied this question.
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