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May 6, 2019Journal of Cellular Physiology

Identification of biomarkers correlated with hypertrophic cardiomyopathy with co‐expression analysis

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Why the study?

Hypertrophic cardiomyopathy is the most common genetic heart disease, but key modules and candidate biomarkers correlated with clinical prognosis remained to be identified.

Population

Model HCM rats and gene expression datasets

Design

Co-expression network analysis (WGCNA) with RT-PCR validation

Authors

TGTiantian GeNational Clinical Research Center for Digestive DiseasesWJWanying JiangFujian Normal UniversityJHJunyu HuoSoochow University

Discussion

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Overview

Immune hub genes upregulated in rat HCM are hypothesis-generating; human validation required before considering therapeutic targeting.

Structured PICO

P
Population
Gene expression datasets for hypertrophic cardiomyopathy (HCM) and model HCM rats
I
Intervention
Weighted Gene Co-expression Network Analysis (WGCNA) and quantitative real-time polymerase chain reaction (RT-PCR)
O
Outcome
Identification of key module and candidate biomarkers correlated with clinical prognosis of patients with HCMsurrogate

Identified immune-related hub genes (TYROBP, CSF1R, and SYK) that are upregulated in HCM, suggesting the immune system plays a crucial role and may offer future therapeutic targets.

Cite This Study

Ge et al. (2019) studied this question.

synapsesocial.com/papers/6a8c456df19228bbb2fb79b3https://doi.org/10.1002/jcp.28762

Topics

Hypertrophic cardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mutation Type Is Not Clinically Useful in Predicting Prognosis in Hypertrophic Cardiomyopathy2010 · 146 citations
  2. 2Targeted Next-Generation Sequencing for the Molecular Genetic Diagnostics of Cardiomyopathies2011 · 178 citations
  3. 3Clinical Course and Management of Hypertrophic Cardiomyopathy2018 · 946 citations
  4. 4Hypertrophic Cardiomyopathy2014 · 655 citations
  5. 5Hypertrophic Cardiomyopathy in Children, Adolescents, and Young Adults Associated With Low Cardiovascular Mortality With Contemporary Management Strategies2015 · 172 citations