Why the study?
Arterial stiffness has been suggested as a major pathological mechanism of cerebral small vessel diseases, but the association between vascular overload index and cSVD required confirmation.
Is vascular overload index (VOI) associated with cerebral small vessel disease (cSVD) in a neurologically healthy population?
Population
3,231 participants undergoing health check-ups between 2006 and 2013
Comparison
Vascular overload index levels
Design
Cross-sectional study
Authors
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May support VOI as cSVD correlate in healthy adults; leaves open causality and need for longitudinal validation.
Is vascular overload index (VOI) associated with cerebral small vessel disease (cSVD) in a neurologically healthy population?
A high vascular overload index (VOI) is significantly associated with cerebral small vessel disease markers (white matter hyperintensity and lacunes) in a neurologically healthy population, particularly among those without hypertension.
Nam et al. (2021) studied this question.
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