October 16, 2013Journal of Cerebral Blood Flow & MetabolismOpen Access

Impaired Cerebrovascular Hemodynamics are Associated with Cerebral White Matter Damage

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Population

48 elderly individuals with vascular risk factors, mean age 75±7 years

Design

Cross-sectional

Authors

SPSushmita PurkayasthaUniversity of North Texas OFOtite FadarBrigham and Women's Hospital AMAujan MehreganKU Leuven

Discussion

Member takes

Implication

May link pulsatile hemodynamics to white matter integrity in vascular-risk elderly; hypothesis-generating and requires longitudinal trials before practice implications.

Structured PICO

Population

48 elderly individuals with vascular risk factors, mean age 75±7 years

Outcome

Relationship between cerebrovascular hemodynamics (pulsatility index and dynamic cerebral autoregulation) and white matter structural integrity (white matter hyperintensity volumes, fractional anisotropy, and mean diffusivity)surrogate

Impaired cerebrovascular hemodynamics are strongly associated with loss of cerebral white matter structural integrity in elderly individuals with vascular risk factors.

Cite This Study

Purkayastha et al. (2013) studied this question.

synapsesocial.com/papers/6a70457afebe604dd7090d83 https://doi.org/10.1038/jcbfm.2013.180

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Implication

May link pulsatile hemodynamics to white matter integrity in vascular-risk elderly; hypothesis-generating and requires longitudinal trials before practice implications.

Impaired Cerebrovascular Hemodynamics are Associated with Cerebral White Matter Damage

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Impaired Cerebrovascular Hemodynamics are Associated with Cerebral White Matter Damage

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider