Key result
Low cerebral blood flow velocity was associated with severe white matter hyperintensities, with an adjusted odds ratio of 4.3 for the lowest versus highest quartile (p=0.001).
Why the study?
Is low cerebral blood flow velocity associated with an increased risk of severe white matter hyperintensities in elderly individuals?
Observational (n=628)
Is low cerebral blood flow velocity associated with an increased risk of severe white matter hyperintensities in elderly individuals?
Odds Ratio: 4.3
p-value: p=0.001
Low cerebral blood flow velocity is strongly associated with severe white matter hyperintensities in elderly individuals, potentially serving as a stronger risk factor than high blood pressure.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for cerebral hemodynamics in white matter disease; leaves open causality and need for longitudinal confirmation before practice change.
Tzourio et al. (2001) conducted an observational in White matter hyperintensities (n=628). Low cerebral blood flow velocity (CBF-V) vs. Highest quartile of mean CBF-V was evaluated on Severe white matter hyperintensities (WMHs) (OR 4.3, p=0.001). Low cerebral blood flow velocity was associated with severe white matter hyperintensities, with an adjusted odds ratio of 4.3 for the lowest versus highest quartile (p=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: