In situ hybridization demonstrates that JHMV RNA persists in specific CNS neurons, such as Purkinje cells, which may serve as viral repositories during prolonged infections.
May indicate neuronal viral reservoirs in paralytic disease; hypothesis-generating in animal models, should not yet change practice.
In situ probing of central nervous system (CNS) tissues has made it possible to associate the presence of JHM virus (JHMV) RNA with individual cells in the rat CNS. The presence of viral RNA was not always associated with antigen expression. The in situ hybridization revealed that cerebellar Purkinje cells and hippocampal neurons were highly susceptible to JHMV infection during either acute or paralytic disease. In the paralytic disease, Purkinje cell neurons frequently contained viral RNA. This observation suggests that these neurons, and perhaps others, may be repositories for JHMV in rats that undergo prolonged infections.
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Sørensen et al. (1985) studied this question.
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