Key result
Transgenic mice with human papovavirus JC early region exhibit a shaking disorder and CNS dysmyelination.
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Establishes transgenic model for JC virus CNS dysmyelination; leaves open relevance to human leukoencephalopathies.
Transgenic mice containing the early region of human papovavirus JC were produced. Some of these mice exhibited a shaking disorder similar to the previously described mutant mice jimpy or quaking. Neuropathological analysis indicated a dysmyelination in the central nervous system, but not the peripheral nervous system. A high level of JCV T-antigen mRNA was present in the brains of the mice exhibiting the myelin disorder. JC virus is associated in humans with a degenerative demyelinating disease: progressive multifocal leukoencephalopathy. The JCV-containing transgenic mice may therefore provide an animal model for studying this disease.
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Small et al. (1986) studied Dysmyelination. Early region of human papovavirus JC was evaluated on Dysmyelination in the central nervous system. Transgenic mice containing the early region of human papovavirus JC exhibited a shaking disorder and dysmyelination in the central nervous system.
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