Key result
Expression of early JCV mRNA depends on tissue-specific factors in glial cells, while viral DNA replication requires a species-specific factor found in primate cells.
The study identifies two levels of regulation for the host range of human papovavirus JCV, involving tissue-specific transcription factors and species-specific replication factors.
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No immediate clinical implications for PML; leaves open JCV host-range mechanisms for human validation.
Feigenbaum et al. (1987) studied Progressive multifocal leukoencephalopathy. JCV T antigen and simian virus 40 T antigen was evaluated on Viral host range regulation and DNA replication. Expression of early JCV mRNA depends on tissue-specific factors in glial cells, while viral DNA replication requires a species-specific factor found in primate cells.
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