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August 17, 1973Science

Human Papovavirus (JC): Induction of Brain Tumors in Hamsters

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Population

Hamsters inoculated at birth

Design

Preclinical

Follow-up

6 months

Authors

DWDuard L. WalkerUniversity of Wisconsin–MadisonBPBillie L. PadgettAustralian National UniversityGZGabriele M. ZuRheinMayo Clinic

Discussion

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Implication

No immediate clinical implications; leaves open JC virus role in human gliomagenesis.

Structured PICO

P
Population
Hamsters inoculated at birth
I
Intervention
Inoculation with JC virus (human papovavirus isolated from brain tissue of a case of progressive multifocal leukoencephalopathy)
O
Outcome
Development of malignant gliomas

JC virus, a human papovavirus, is capable of inducing malignant gliomas in hamsters.

Cite This Study

Walker et al. (1973) studied this question.

synapsesocial.com/papers/6a866745894d3eb3a35af6behttps://doi.org/10.1126/science.181.4100.674
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PROGRESSIVE MULTIFOCAL LEUKO-ENCEPHALOPATHY1958 · 837 citations
  2. 2Poliovirus Replication and Cytopathogenicity in Monolayer Hamster Cell Cultures Fused with Beta Propiolactone-Inactivated Sendai Virus1968 · 116 citations
  3. 3DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE1964 · 426 citations