Lower Limb Paralysis Induced in Mice by a Temperature-Sensitive Mutant of Moloney Leukemia Virus2

View Full Paper

Ask AI

Bookmark

Population

Newborn mice and inbred W/Fu rats

Design

Preclinical

Authors

Discussion

Host strain dictates ts-MuLV paralysis in mice; leaves open human retroviral neuropathy relevance.

Population

Newborn mice (inbred strains CFW/D, CBA/H, C3H/Bi/Ka, C57BL/Ka, and outbred NIH Swiss stock) and inbred W/Fu rats

Intervention

Injection with a temperature-sensitive mutant of Moloney murine leukemia virus defective in an early function

Outcome

Development of lower limb paralysis

A temperature-sensitive mutant of Moloney murine leukemia virus induces lower limb paralysis in specific susceptible strains of newborn mice.

McCarter et al. (1977) studied this question.

View Full Paper

Ask AI

Bookmark