Why the study?
Does passive immunization with antiserum to murine leukemia virus prevent paralysis and lymphoma in newborn Lake Casitas wild mice?
Does passive immunization with antiserum to murine leukemia virus prevent paralysis and lymphoma in newborn Lake Casitas wild mice?
Passive immunization of newborn wild mice with antiserum to murine leukemia virus completely prevents paralysis but does not significantly reduce lymphoma incidence or total mortality.
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Hypothesis-generating in this murine retroviral model; leaves open any clinical translation to human disease prevention.
Lake Casitas wild mice were passively immunized as newborns with antiserum to congenitally transmitted murine leukemia virus. Immunization with immunoglobulin having a high neutralizing titer to ecotropic virus and a low titer to amphotropic virus correlated with the complete prevention of paralysis and a slight (25%), but statistically insignificant, reduction in the incidence of lymphoma. Occurrence of other tumor types and total mortality rate were not affected by immunization.
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Gardner et al. (1980) studied this question.
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