⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

May 1, 1989Journal of VirologyOpen Access

Survival of athymic (nu/nu) mice after Theiler's murine encephalomyelitis virus infection by passive administration of neutralizing monoclonal antibody

View Full Paper

Ask AI

Bookmark

Share

Why the study?

Does neutralizing monoclonal antibody against VP-1 improve survival and reduce viral replication in athymic mice infected with Theiler's murine encephalomyelitis virus?

Population

37 mice infected intracerebrally with the Daniels strain of Theiler's murine encephalomyelitis virus at 4…

Comparison

Neutralizing monoclonal antibody against TMEV… vs Untreated infected nu/nu and nu/+ mice.

Design

Preclinical

Follow-up

up to 3 months

Authors

RFRobert S. FujinamiUniversity of Utah ARAlan RosenthalMerck & Co., Inc., Rahway, NJ, USA (United States)PLPeter W. LampertKarlstad University

Discussion

Loading...

Member takes

Implication

Supports antibody strategies in immunodeficient viral models; leaves open translation to human demyelinating disease.

Structured PICO

Does neutralizing monoclonal antibody against VP-1 improve survival and reduce viral replication in athymic mice infected with Theiler's murine encephalomyelitis virus?

P

Population

37 mice (24 homozygous athymic nu/nu and 13 heterozygous nu/+ nude mice) infected intracerebrally with the Daniels strain of Theiler's murine encephalomyelitis virus (TMEV) at 4 weeks of age.

I

Intervention

Neutralizing monoclonal antibody (H7-2) against TMEV viral protein VP-1, administered intraperitoneally on days 2, 4, 6, 8, 10, 13, 16, 19, 23, 27, and 31 postinfection.

C

Comparator

Untreated infected nu/nu and nu/+ mice.

O

Outcome

Survival, viral replication in the central nervous system, and morphological pattern of disease (demyelination and remyelination) at 1 to 3 months postinfection.surrogate

Passive administration of a neutralizing monoclonal antibody against TMEV VP-1 promotes survival, viral clearance, and remyelination in immunodeficient mice.

Cite This Study

Fujinami et al. (1989) studied this question.

synapsesocial.com/papers/6a8af4a906ce16d944b1ea3a https://doi.org/10.1128/jvi.63.5.2081-2087.1989

View Full Paper

Ask AI

Bookmark

Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Central Nervous System Immunity in Mice Infected with Theiler's Virus. I. Local Neutralizing Antibody Response1978 · 62 citations
2A neutralization-resistant Theiler's virus variant produces an altered disease pattern in the mouse central nervous system1989 · 54 citations
3Theiler's virus infection in nude mice: viral RNA in vascular endothelial cells1988 · 53 citations
4Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination1975 · 611 citations
5The Effect of L3T4 T Cell Depletion on the Pathogenesis of Theiler's Murine Encephalomyelitis Virus Infection in CBA Mice1987 · 155 citations