⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

October 1, 1988Journal of VirologyOpen Access

Theiler's virus infection in nude mice: viral RNA in vascular endothelial cells

View Full Paper

Ask AI

Bookmark

Share

Population

Athymic (nu/nu) mice infected with the Daniels strain of Theiler's murine encephalomyelitis virus

Design

Preclinical

Authors

AZAndreas ZurbriggenNihon University RFRobert S. FujinamiUniversity of Utah

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for endothelial viral entry in this mouse model; leaves open relevance to human CNS infections.

Structured PICO

P

Population

Athymic (nu/nu) mice infected with the Daniels strain of Theiler's murine encephalomyelitis virus

I

Intervention

Infection with the Daniels strain of Theiler's murine encephalomyelitis virus

O

Outcome

Presence of viral proteins and RNA in the nervous system, specifically in vascular endothelial cellssurrogate

Theiler's virus RNA is present in vascular endothelial cells of infected nude mice, suggesting a mechanism for viral spread across the blood-brain barrier.

Cite This Study

Zurbriggen et al. (1988) studied this question.

synapsesocial.com/papers/6a8af4ab06ce16d944b1ea3b https://doi.org/10.1128/jvi.62.10.3589-3596.1988

View Full Paper

Ask AI

Bookmark

Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1OBSERVATIONS ON ENCEPHALOMYELITIS OF MICE (DA STRAIN)1952 · 159 citations
2Theiler's virus antigen detected in mouse spinal cord 2½ years after infection1984 · 97 citations
3Theiler's virus genome is closely related to that of encephalomyocarditis virus, the prototype cardiovirus1986 · 45 citations
4Analysis of the complete nucleotide sequence of the picornavirus Theiler's murine encephalomyelitis virus indicates that it is closely related to cardioviruses1987 · 180 citations
5Demyelinating lesions due to Theiler's virus are associated with ongoing central nervous system infection1986 · 88 citations