Why the study?
Does monoclonal antibody therapy targeting T cell subsets improve outcomes in mice with Theiler's virus-induced demyelination?
Population
Mice with Theiler's murine encephalomyelitis virus-induced demyelination
Design
Preclinical
Follow-up
6 to 8 weeks
Authors
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Differential T-cell subset effects in this murine model; leaves open translation to human demyelinating disease.
Does monoclonal antibody therapy targeting T cell subsets improve outcomes in mice with Theiler's virus-induced demyelination?
Class I-restricted T cells may be critical during demyelination, while class II-restricted T cells are important during early disease to prevent overwhelming encephalitis in a murine model.
Moses Rodriguez (1988) studied this question.
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