July 1, 1986Neurology

Partial suppression of Theiler's virus‐induced demyelination in vivo by administration of monoclonal antibodies to immune‐response gene products (Ia antigens)

View Full Paper

Ask AI

Bookmark

Population

SJL/J (H-2s) mice persistently infected with Theiler's murine encephalomyelitis virus

Design

Preclinical

Authors

MRMoses RodriguezFlorida State University WLWilliam P. LafuseThe Ohio State University JLJulian L. LeibowitzTexas A&M Health Science Center

Discussion

Member takes

Implication

Hypothesis-generating in a viral demyelination model; leaves open whether Ia-targeted therapy merits human investigation.

Structured PICO

Population

SJL/J (H-2s) mice persistently infected with Theiler's murine encephalomyelitis virus

Intervention

In vivo administration of monoclonal antibody reactive with major histocompatibility complex-encoded Ia molecules (I-As)

Outcome

Inflammation and demyelination in the spinal cordsurrogate

Administration of monoclonal antibodies to Ia antigens partially suppresses Theiler's virus-induced demyelination, suggesting mediation by immune cells carrying Ia class II molecules.

Cite This Study

Rodriguez et al. (1986) studied this question.

synapsesocial.com/papers/6a905ee002529ca22a27915d https://doi.org/10.1212/wnl.36.7.964

View Full Paper

Ask AI

Bookmark

Partial suppression of Theiler's virus‐induced demyelination in vivo by administration of monoclonal antibodies to immune‐response gene products (Ia antigens)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Partial suppression of Theiler's virus‐induced demyelination in vivo by administration of monoclonal antibodies to immune‐response gene products (Ia antigens)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider