The kinetic binding mechanism of rat kidney gamma-glutamylcysteine synthetase has been evaluated by isotope exchange at equilibrium studies. The results are consistent with a Random BC mechanism as suggested previously (Yip, B. P., and Rudolph, F. B. (1976) J. Biol. Chem. 251, 3563-3568). The purification procedure for the enzyme was modified to remove contaminating adenylate kinase prior to isotope exchange studies.
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Schandle et al. (1981) studied this question.
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