Extensive Cutaneous Moniliasis

Chronic extensive cutaneous and oral moniliasis, occasionally seen in childhood, is of interest not only because of the therapeutic problems involved in the management of the infection but also because of unanswered questions regarding its pathogenesis. The association of moniliasis in some cases with conditions such as hypoadrenalism, hypoparathyroidism, hypothyroidism, and a malabsorption syndrome is of great interest in consideration of the possible factors involved in the pathogenesis of the infection. While the more common, less extensive monilial infections in childhood, such as oral thrush, are relatively easily controlled by the local use of methylrosaniline chloride and nystatin, the chronic extensive infections are usually resistant to treatment.1-3 Amphotericin B, a new antibiotic agent, has recently been shown to be effective in the treatment of generalized North American blastomycosis, coccidioidomycosis, and histoplasmosis.4-7Experimental work with this new fungistatic agent has been carried out since 1955. First obtained in the