What question did this study set out to answer?

To evaluate contact allergy rates to citral and its constituent aldehydes, geranial and neral, as well as cross-reactivity with oxidized geraniol and baseline fragrance markers.

October 1, 2019Contact Dermatitis

Contact allergy to citral and its constituents geranial and neral, coupled with reactions to the prehapten and prohapten geraniol

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Authors

LHLina HagvallLund University MBM. BruzeMalmö University MEMalin EngfeldtLund University

Discussion

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Implication

Observational study reveals frequent contact allergy to citral components and oxidized geraniol in dermatitis patients, indicating baseline screening series miss key fragrance sensitizers.

Key Points

To evaluate contact allergy rates to citral and its constituent aldehydes, geranial and neral, as well as cross-reactivity with oxidized geraniol and baseline fragrance markers.
Patch tested 1476 dermatitis patients suspected of allergic contact dermatitis using the Swedish baseline series alongside additional fragrance compounds.
Tested citral (3.5% pet.), geranial (3.5% pet.), neral (3.5% pet.), geraniol (6.0% pet.), and oxidized geraniol (11% pet.).
Positive patch test frequencies were 2.9% for citral, 3.4% for geranial, and 1.9% for neral, with citral and geranial jointly producing positive reactions in 4.2% of patients.
Among individuals with positive reactions to citral or its components, 25% to 34% reacted to fragrance mix II and 61% reacted to oxidized geraniol, whereas pure geraniol yielded negligible utility.

Cite This Study

Hagvall et al. (2019) studied this question.

synapsesocial.com/papers/6a8c5c94ef2dbea76bab904d https://doi.org/10.1111/cod.13404

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Implication

Observational study reveals frequent contact allergy to citral components and oxidized geraniol in dermatitis patients, indicating baseline screening series miss key fragrance sensitizers.

Contact allergy to citral and its constituents geranial and neral, coupled with reactions to the prehapten and prohapten geraniol

Discussion

Member takes

Implication

Key Points

Cite This Study

Contact allergy to citral and its constituents geranial and neral, coupled with reactions to the prehapten and prohapten geraniol

Discussion

Member takes

Implication

Key Points

Cite This Study

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