Why the study?
Does withdrawal of antihypertensive drugs affect the frequency of symptoms in hypertensive patients?
Does withdrawal of antihypertensive drugs affect the frequency of symptoms in hypertensive patients?
Withdrawal of antihypertensive therapy significantly reduces most symptoms except headache, suggesting that many symptoms in treated hypertensive patients are drug-related adverse effects.
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May suggest drug-related symptoms in treated hypertension; hypothesis-generating for randomized deprescribing trials.
We have evaluated the effect of withdrawal of antihypertensive drugs on the frequency of symptoms over a 2-week period in 11,710 hypertensive patients. Previously untreated patients complained most frequently of headache, dizziness and chest pain, whereas most other symptoms occurred more often in previously treated patients. With the exception of headache, which rose in frequency, most symptoms showed a significant reduction following therapy withdrawal. The burden of symptoms reported by treated hypertensive patients is probably the result of a combination of their disease, drug-related adverse effects and inappropriate use of drugs in certain patient groups.
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Cooper et al. (1988) studied this question.
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