Levels of Cornell Voltage and Cornell Product for Predicting Cardiovascular and Stroke Mortality and Morbidity in the General Japanese Population

BACKGROUND: ECG-diagnosed left ventricular hypertrophy (LVH), the Cornell voltage (CV: ≥2.8mV in males and ≥2.0mV in females) or Cornell product (CP: ≥244.0mV×ms), were selected in Western countries for their ability to diagnose anatomical LVH. METHODS AND RESULTS: We aimed to elucidate the CV and CP values that were associated with a significantly increased risk of cardiovascular or stroke mortality and morbidity in a Japanese general population (n=10,172). In the receiver-operating curves analysis of CV and CP for predicting the risks, the area under the curve in females was greater than in males. In a quintile-based multivariate analysis that was performed separately for females and males, the mortality and morbidity risks of CV were significantly increased at the highest quintile of CV (>1.71mV) in females. In males, the mortality risk was significantly increased at the highest quintile of CV (>2.04mV). Additionally, in the parallel analysis of CP that included both males and females, the morbidity risk was significantly elevated in subjects with CP belonging to the 4th (158.7-193.4mV×ms; hazard ratio=1.387) or 5th quintiles (≥193.5mV×ms; hazard ratio=1.507), compared with those with CP values within the lowest quintile (<101.9mV×ms). CONCLUSIONS: Cardiovascular and stroke risks may be elevated at lower levels of CV and CP in Japanese subjects, especially females.