What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Left ventricular hypertrophy (n=332). Intervention: Cornell voltage criteria vs. Sokolow-Lyon voltage criteria. Primary outcome: Diagnostic performance (Area Under the ROC Curve) for detecting LVH (LVM/height2.7) in females (95% CI 0.713-0.841, p=0.007).

What question did this study set out to answer?

To compare the diagnostic performance of Cornell and Sokolow-Lyon electrocardiographic criteria for detecting left ventricular hypertrophy in Korean patients.

January 1, 2012Sunhwan'giOpen Access

A Comparison of Cornell and Sokolow-Lyon Electrocardiographic Criteria for Left Ventricular Hypertrophy in Korean Patients

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Key result

Cornell voltage criteria demonstrated significantly better diagnostic performance for left ventricular hypertrophy compared to Sokolow-Lyon criteria in Korean patients, with an AUC of 0.782 vs 0.644 in females.

Why the study?

Do Cornell-based ECG criteria improve diagnostic performance for detecting left ventricular hypertrophy compared to Sokolow-Lyon criteria in Korean patients?

Key Points

To compare the diagnostic performance of Cornell and Sokolow-Lyon electrocardiographic criteria for detecting left ventricular hypertrophy in Korean patients.
Analyzed electrocardiography and echocardiographic left ventricular mass data from 332 consecutive Korean patients (159 male, 173 female).
Compared Cornell voltage criteria and Cornell product against Sokolow-Lyon voltage and product using receiver-operating characteristic curve analysis at 90%, 95%, and 100% specificity.
Cornell-based criteria generally demonstrated higher area under the receiver-operating characteristic curve values than Sokolow-Lyon voltage and product criteria.
Revised Cornell voltage thresholds of 20 mm in males and 16 mm in females achieved improved sensitivities of 19.7% and 30.3%, respectively, at 95% specificity.

Study Design

Type

Cross-Sectional (n=332)

Blinding

Single-blind

Multicenter

Structured PICO

Do Cornell-based ECG criteria improve diagnostic performance for detecting left ventricular hypertrophy compared to Sokolow-Lyon criteria in Korean patients?

Population

332 consecutive Korean patients (mean age 53, 52% female) who underwent ECG and echocardiography, evaluated to compare diagnostic criteria for left ventricular hypertrophy.

Exposure

Cornell-based electrocardiographic criteria (Cornell voltage and Cornell product) for diagnosing left ventricular hypertrophy

Comparator

Sokolow-Lyon electrocardiographic criteria (Sokolow-Lyon voltage and Sokolow-Lyon product)

Outcome

Diagnostic performance (sensitivity, specificity, and area under the ROC curve) for detecting echocardiographic left ventricular hypertrophysurrogate

Main Result

Absolute Event Rate: 0.782% vs 0.644%

p-value: p=0.007

Limitations

Retrospective design from a single center patient population with a high prevalence of hypertension and diabetes.
Age distribution may differ from the general population (fewer young females).
Small number of obese patients included.
Some patients were on pharmacological treatment which may have affected the results.
Conventional cut-off values were derived from young normotensive individuals, potentially biasing results in this older cohort.
Retrospective design from a patient population with hypertension and diabetes prevalence differing from the general population
Age distribution differences compared to the general population
Small number of obese patients
Some patients were previously on pharmacological treatment

Discussion

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Implication

Cornell criteria may outperform Sokolow-Lyon for LVH detection in Koreans; leaves open need for race-specific cutoffs before broader adoption.

Cite This Study

Park et al. (2012) conducted a cross-sectional in Left ventricular hypertrophy (n=332). Cornell voltage criteria vs. Sokolow-Lyon voltage criteria was evaluated on Diagnostic performance (Area Under the ROC Curve) for detecting LVH (LVM/height2.7) in females (95% CI 0.713-0.841, p=0.007). Cornell voltage criteria demonstrated significantly better diagnostic performance for left ventricular hypertrophy compared to Sokolow-Lyon criteria in Korean patients, with an AUC of 0.782 vs 0.644 in females.

synapsesocial.com/papers/6a6d1312ce524a4339c2a86e https://doi.org/10.4070/kcj.2012.42.9.606

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Implication

Cornell criteria may outperform Sokolow-Lyon for LVH detection in Koreans; leaves open need for race-specific cutoffs before broader adoption.

A Comparison of Cornell and Sokolow-Lyon Electrocardiographic Criteria for Left Ventricular Hypertrophy in Korean Patients

Key Points

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

A Comparison of Cornell and Sokolow-Lyon Electrocardiographic Criteria for Left Ventricular Hypertrophy in Korean Patients

Key Points

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider