April 29, 2019Journal of Pharmacological SciencesOpen Access

Knockdown of Sfrp4 attenuates apoptosis to protect against myocardial ischemia/reperfusion injury

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Why the study?

Secreted frizzled-related protein 4 is involved in cardiac development and cardiovascular diseases, but its role in mediating myocardial ischemia/reperfusion injury was unknown.

Does knockdown of Sfrp4 attenuate myocardial ischemia/reperfusion injury in mice?

Population

Mice subjected to myocardial ischemia/reperfusion injury

Comparison

Knockdown of Sfrp4 via Ad-shSfrp4 vs control

Design

Animal experimental study

Authors

WZWenhui ZengSouthwest University YCYu CaoHuazhong Agricultural University WJWanli JiangWuhan University

Discussion

Member takes

Implication

Supports Sfrp4-AKT targeting for myocardial I/R injury in mice; leaves open translation to human cardioprotection.

Structured PICO

Does knockdown of Sfrp4 attenuate myocardial ischemia/reperfusion injury in mice?

Population

Mice subjected to myocardial ischemia/reperfusion injury

Intervention

Adenoviral (Ad)-shSfrp4 adenoviruses to knockdown Sfrp4 in myocardium

Outcome

Myocardial ischemia/reperfusion injury (measured by lactate dehydrogenase, creatine kinase, and ventricular function)surrogate

Knockdown of Sfrp4 protects against myocardial ischemia/reperfusion injury by reducing apoptosis via the AKT signaling pathway in a mouse model.

Cite This Study

Zeng et al. (2019) studied this question.

synapsesocial.com/papers/6a8c641a3e9737de6060ec7f https://doi.org/10.1016/j.jphs.2019.04.003

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Knockdown of Sfrp4 attenuates apoptosis to protect against myocardial ischemia/reperfusion injury

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Knockdown of Sfrp4 attenuates apoptosis to protect against myocardial ischemia/reperfusion injury

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider