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August 1, 1999Nucleosides and Nucleotides

Synthesis of Dimer Phosphoramidite Synthons for Oligodeoxyribonucleotide Phosphorothioates Using Diethyldithiocarbonate disulfide as an Efficient Sulfurizing Reagent

Alessandra Eleuteri Zacharia S. Cheruvallath Daniel C. Capaldi Douglas L. Cole Vasulinga T. Ravikumar

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Abstract

An efficient solution phase synthesis of deoxyribonucleoside phosphorothioate dimers utilizing phosphoramidite approach is described. Diethyldithiocarbonate disulfide (DDD) was found to be an efficient sulfurizing reagent in the conversion of phosphite triesters to phosphorothioate triesters.

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Eleuteri et al. (1999) studied this question.

synapsesocial.com/papers/6a8c66afc4ebc3188960eaa2 https://doi.org/10.1080/07328319908044844

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