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July 1, 1997Nucleosides and Nucleotides

Evaluation of Sulfur-Transfer Reagents for Large Scale Synthesis of Oligonucleotide Phosphorothioate Analogues

Zhaoda Zhang Alexandra Nichols Jimmy X. Tang Mazen Alsbeti Jin Tang

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Abstract

Several sulfur-transfer reagents have been evaluated for large scale synthesis of oligonucleotide phosphorothioate analogues, in which 3-ethoxy-1, 2-dithiazoline-5-one (EDITH, 5) shows potential as an alternative to Beaucage reagent.

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Zhang et al. (1997) studied this question.

synapsesocial.com/papers/6a8c66afc4ebc3188960eaa6 https://doi.org/10.1080/07328319708006235

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