Why the study?
Does the loss of miR-155 prevent pathological cardiac hypertrophy and heart failure in mouse models?
Does the loss of miR-155 prevent pathological cardiac hypertrophy and heart failure in mouse models?
Loss of miR-155 protects against pathological cardiac hypertrophy and extends survival in mouse models, identifying it as a potential therapeutic target for heart failure.
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Supports miR-155 inhibition as a heart failure target in mice; leaves open translation to clinical therapy.
Seok et al. (2014) studied this question.
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