Why the study?
The study was conducted to examine the presence and function of pannexins in the porcine splenic artery in which 1A-adrenoceptors are present.
Pannexin-1 and -2 are expressed in the porcine splenic artery, and non-selective pannexin inhibitors reduce noradrenaline-induced vasoconstriction, suggesting a role for pannexins in vascular tone regulation.
Supports preclinical vascular research on pannexin channels; leaves open any human therapeutic relevance.
Background: Pannexins are newly discovered proteins that were first discovered by This aim of this work was to examine the presence and function of pannexins in the porcine splenic artery (PSA) in which 1A -adrenoceptors is present.
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Alaa Hamed Habib (2020) studied this question.
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