There are strong demands for innovation in methodology for separation of B cells and T cells, two major subpopulations of lymphocytes, because of their essential role as key-factors for therapy and diagnosis of immuno-diseases as well as for production of high-value bioactive compounds. Cellular adsorption chromatography is one of the promising methods for separation of these lymphocyte subpopulations. This paper reviews the present status of adsorption chromatography applied to the cell separation and describes our approach to design of novel adsorbents which are able to adsorb B cells selectively among other subpopulations without any undesirable perturbation or activation of cells to be separated. A possible mechanism involved in separation of B and T cells by adsorption chromatography is also discussed in detail.
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Kataoka et al. (1985) studied this question.
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