Complement Proteins C3 and C4 Bind to Collagen and Elastin in the Vascular Wall: A Potential Role in Vascular Stiffness and Atherosclerosis
Population
ApoE(-/-) and C57Bl/6J control mice
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Supports hypothesis of perivascular complement activation in atherosclerosis; leaves open relevance to human vascular stiffness.
Structured PICO
P
Population
ApoE(-/-) and C57Bl/6J control mice
I
Intervention
Ultrastructural identification of C3- and C4-binding targets within the adventitia of the mouse aorta
O
Outcome
Binding of C3 and C4 to collagen and elastin fibers within the adventitiasurrogate
Complement proteins C3 and C4 bind to collagen and elastin in the adventitia, suggesting a potential 'outside-in' mechanism for vascular stiffness and atherosclerosis driven by perivascular adipose tissue.
Cite This Study
Shields et al. (2011) studied this question.